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Cat. No.: HY-P1193

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GR 82334

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

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CAS No.: 129623-01-4
Formule: C₆₉H₉₁N₁₅O₁₆
Masse moléculaire:1386.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

GR 82334 Chemical Structure

CAS No.: 129623-01-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist^[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats^[1].

Voir tous les produits spécifiques à Isoform Neurokinin Receptor :

In Vivo

GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)^[1].
GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats^[2]
Dosage:

10 nM, 100 nM, and 1 µM
Administration:

Lntrathecal injection between vertebrae L4 and L5
Result:

Increased heat-induced foot withdrawal latency in mice.

Chemical Information

CAS No. 129623-01-4
Masse moléculaire 1386.55
Formule C₆₉H₉₁N₁₅O₁₆
Sequence

{Glp}-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-{d-Pro(spiro-γ-lactam)Leu}-Trp-NH2
Sequence Shortening

{Glp}-ADPNKFY-{d-Pro(spiro-γ-lactam)Leu}-W-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci [Content Brief]

[2]. Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références

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GR 82334

Voir tous les produits spécifiques à Isoform Neurokinin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GR 82334 Related Classifications

HY-P1193 Related Classifications