HC102A

HC102A (0.01-100 μM) potently and selectively inhibits DosR-dependent GFP fluorescence in Mtb CDC1551 (hspX′::GFP), with an EC₅₀ of 12.4 μM^[1].
HC102A (40 μM; 6 days) reduces TAG accumulation by 67% in Mtb CDC1551, thereby disrupting a key lipid metabolic process associated with persistence^[1].
HC102A (1-100 μM; 10 days) reduces the survival rates of Mtb CDC1551 and Erdman strains in a dose-dependent manner under hypoxic NRP conditions, and decreases the strain survival rate by approximately 50% at a dose of 10 μM^[1].
HC102A (1 h) directly inhibits autophosphorylation of purified Mtb DosS protein with an IC₅₀ of 1.9 μM, but has minimal effect on autophosphorylation of DosT^[1].
HC102A directly inhibits the autophosphorylation activity of the Mycobacterium tuberculosis DosS sensor kinase, but exerts no such effect on the DosT sensor kinase^[2].
HC102A inhibits the autokinase activity of DosS and DosT histidine kinases in *Mycobacterium tuberculosis*, reduces the hypoxia-induced survival rate of *Mycobacterium tuberculosis*, and exhibits extremely low cytotoxicity against mammalian cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.