HC103A
HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC50 of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis.
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- CAS No.: 312595-37-2
- Formule: C18H14N2O3S
- Masse moléculaire:338.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
HC103A (0.1-100 μM; 6 d) potently and selectively inhibits DosR-dependent GFP fluorescence in Mycobacterium tuberculosis CDC1551(hspX′::GFP) with an EC50 of 2.7 μM without affecting bacterial growth[1].
HC103A (40 μM) reduces triacylglycerol accumulation by 56% in Mycobacterium tuberculosis CDC1551, disrupting a key persistence-associated lipid metabolism pathway[1].
HC103A (0-60 μM; 1 h) directly inhibits autophosphorylation of purified Mycobacterium tuberculosis DosS (IC50 0.5 μM) and DosT (IC50 ~5 μM) sensor kinases without altering their heme redox status[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 312595-37-2
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Masse moléculaire 338.38
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Formule C18H14N2O3S
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SMILES
O=C(NC1=CC=CC(=C1)C(=O)NC=2C=CC=C(O)C2)C=3SC=CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol. 2017;13(2):218-225. [Content Brief]
[2]. Zheng H, et al. Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme. ACS Chem Biol. 2020 Jan 17;15(1):52-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HC103A Related Classifications
HY-165396 Related Classifications
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