HSK205
Based on 1 Customer Validation
HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.01%
- CAS No.: 3022263-37-9
- Formule: C26H24N6O
- Masse moléculaire:436.51
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Blood Cancer Compound Library
HY-L079
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Membrane Protein-targeted Compound Library
HY-L149
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Cytokine Inhibitors Library
HY-L161
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| MOLM-14 | GI50 |
2.2 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
22.4 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
4.3 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MV4-11 | GI50 |
8.9 nM
Compound: 14; HSK205
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Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
Chemical Information
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CAS No. 3022263-37-9
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Appearance Solid
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Masse moléculaire 436.51
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Formule C26H24N6O
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Color Off-white to light yellow
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SMILES
O=C(NCC1=NC(C)=CN1)C(C=C2)=CC=C2C(C3=C4CCCC3)=NC5=C4C(C=NN6)=C6C=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 4.17 mg/mL (9.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2909 mL | 11.4545 mL | 22.9090 mL | 57.2725 mL |
| 5 mM | 0.4582 mL | 2.2909 mL | 4.5818 mL | 11.4545 mL |
HSK205 Related Classifications
HY-155341 Related Classifications
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