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Cat. No.: HY-185697A

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Inact-dIRF4-2

Inact-dIRF4-2 is an inactive control compound of dIRF4-2 (HY-185697). Inact-dIRF4-2 lacks IRF4-binding activity and IRF4-dependent cytotoxic activity. Inact-dIRF4-2 can be used in the research of multiple myeloma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3136609-65-6
Formule: C₄₃H₄₆N₈O₇
Masse moléculaire:786.87

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Inact-dIRF4-2 Chemical Structure

CAS No.: 3136609-65-6

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC50	50 μM	Cytotoxicity against human HEK293T cells assessed as cell viability incubated for 96 hrs by CellTiter-Glo assay, with IC₅₀ greater than 50 μM. Cytotoxicity against human HEK293T cells assessed as cell viability incubated for 96 hrs by CellTiter-Glo assay, with IC₅₀ greater than 50 μM.	42209806

In Vitro

Inact-dIRF4-2 (96 h) does not induce cytotoxicity in 11 of 12 tested cell lines (including 11 IRF4-dependent multiple myeloma cell lines and the IRF4-independent HEK293T cell line), with IC₅₀ values >50 μM, confirming IRF4-dependent cell killing by the active degrader dIRF4-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Karpas-707, RPMI-8226, JIN-3, MM1.S, AMO1, KMS-12-BM, OPM-2, KMS-11, LP-1, EJM, U266B1, MOLP-2, HEK293T
Concentration:

>50 μM
Incubation Time:

96 h
Result:

Showed no cytotoxic effects in 11 out of 12 tested cell lines, with IC₅₀ values greater than 50 μM across all doses.

Chemical Information

CAS No. 3136609-65-6
Masse moléculaire 786.87
Formule C₄₃H₄₆N₈O₇
SMILES

COC1=CC=C(C2(CC2)C(N[C@@H](C(NC)=O)C3=CC=CC(C4=CN(CCCN5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)N=C4)=C3)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Agius MP, et al. Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma. Nature chemical biology. 2026 May 28. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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