ING-1
ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers.
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- Pureté: 99.0%
- Masse moléculaire:145.77 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human IgG1 kappa
Human
EpCAM/TROP1/CD326
ING-1(0.1-10000 nM, 4°C for 5 h) competes similarly with radiolabeled chimeric ING-1 for binding to Ep-CAM in HT -29 human cells, with an Kd of 2 to 5 nM[1].
ING-1(37°C for 4 h) caused a concentration-dependent lysis of 51Cr-labeled BT-20, MCF-7, HT-29, CACO-2, NCI-H1568, PC-3, HPAF-II cells in ADCC and CDC activity assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT-29 xenograft (3x106/1.5x107) nude mice (20-25 g) model[1][2]
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Dosage:0.1, 0.3, or 1 mg/kg
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Administration:i.v., one/two doses per week, 3 weeks
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Result:Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 64% reduction in tumor size at the end of the experiment at 1 mg/kg.
Eliminated visible tumor nodules in body cavities of some animals, reduced tumor metastases on lung surfaces, resulted in 86% reduction of the average number of metastases at 1 mg/kg.
Inhibited micrometastases formation in Lung Tissues, reduced the average number of micrometastasis foci by 91% at 1 mg/kg.
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Animal Model:PC-3 xenograft (5x106) nude mice (20-25 g) model[1]
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Dosage:0.1, 0.3, or 1 mg/kg
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Administration:i.v., two doses per week, 3 weeks
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Result:Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 71% reduction in tumor size at the end of the experiment at 1 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized Human EpCAM Protein, His Tag can bind ING-1. The EC50 for this effect is 29.2 ng/mL.
Chemical Information
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Appearance Liquid
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Masse moléculaire 145.77 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
heMab
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Ammons WS, et al. In vitro and in vivo pharmacology and pharmacokinetics of a human engineered monoclonal antibody to epithelial cell adhesion molecule. Neoplasia. 2003 Mar-Apr;5(2):146-54. [Content Brief]
[2]. Ruan HH, et al. ING-1(heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model. Neoplasia. 2003 Nov-Dec;5(6):489-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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