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Cat. No.: HY-173413

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Insecticidal agent 21

Insecticidal agent 21 (Compound 6) is an insecticide that is effective against Culex pipiens larvae (LC₅₀: 0.4 μg/mL). Insecticidal agent 21 achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors (nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR)). Insecticidal agent 21 has a strong insecticidal effect and can be used in the development of new insecticides to address the problem of mosquito resistance to traditional insecticides.

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CAS No.: 3082443-45-3
Formule: C₃₇H₄₀ClN₃O₂
Masse moléculaire:594.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Insecticidal agent 21 Chemical Structure

CAS No.: 3082443-45-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

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Chemical Information

CAS No. 3082443-45-3
Masse moléculaire 594.19
Formule C₃₇H₄₀ClN₃O₂
SMILES

CCCCCCCCCCCC(NN1C(/C(C=C1C2=CC=C(C)C=C2)=C/C3=CC4=CC=C5C(C=CC=C5)=C4N=C3Cl)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Animals and Diseases

Neurotoxicity Study
This protocol assesses in vitro neurotoxicity by combining neuronal viability, mitochondrial/metabolic activity, neurite outgrowth, and optional neuronal network function readouts. Calcein-AM or resazurin/PrestoBlue readouts estimate viable or metabolically active cells; βIII-tubulin immunofluorescence detects neuronal morphology and neurite networks; TMRE detects mitochondrial membrane potential; and MEA recordings detect functional changes in neuronal network activity.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. El-Helw EAE, et al. Synthesis of Benzo[h]quinoline derivatives and evaluation of their insecticidal activity against Culex pipiens L. larvae. Eur J Med Chem. 2025 Jun 5;290:117565. [Content Brief]

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Activité biologique
- Description
Chemical Information
Protocole
Pureté et documentation
Références

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Insecticidal agent 21

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

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