Isosulfazecin
Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics.
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- CAS No.: 77900-75-5
- Formule: C12H20N4O9S
- Masse moléculaire:396.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 77900-75-5
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Masse moléculaire 396.37
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Formule C12H20N4O9S
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SMILES
OC([C@H](N)CCC(N[C@@H](C)C(N[C@@]1(C(N(S(=O)(O)=O)C1)=O)OC)=O)=O)=O
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Structure Classification
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Initial Source
Pseudomonas mesoacidophila sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isosulfazecin Related Classifications
HY-121120 Related Classifications
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