JBC117
Based on 1 Customer Validation
JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis.
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- Pureté: 99.71%
- CAS No.: 1214531-21-1
- Formule: C28H30N2O3
- Masse moléculaire:442.55
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Anti-Lung Cancer Compound Library
HY-L075
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
JBC117 (20 μM, 24 h) inhibits the growth of colon cancer (HCT116) and lung cancer (A549) with IC50 values of 2.6 and 3.3 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, A549
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Concentration:5, 10, 20 μM
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Incubation Time:72 h
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Result:Downregulated the expression level of Wnt downstream target genes, including Axin2, c-myc and cyclin D1.
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Cell Line:HCT116, A549
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Concentration:20 μM
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Incubation Time:24 h
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Result:Decreased the ability to migrate and invasion in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse xenograft models of colon and lung cancer[1]
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Dosage:20 mg/kg
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Administration:s.c. for 14 days
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Result:Reduced colon and lung tumor growth by 65% and 93%, respectively.
Increased apoptosis in the tumor sections.
Chemical Information
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CAS No. 1214531-21-1
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Appearance Solid
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Masse moléculaire 442.55
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Formule C28H30N2O3
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Color White to off-white
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SMILES
OC(CN1CCC2(CC1)OC3=C(C(C2)O)C=CC4=C3C=CC=C4)C5=CNC6=C5C=CC(C)=C6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JBC117 Related Classifications
HY-157891 Related Classifications
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