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Cat. No.: HY-156399

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KR-27425

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE).

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CAS No.: 3047755-18-7
Formule: C₁₀H₂₁N₃O₂
Masse moléculaire:215.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

KR-27425 Chemical Structure

CAS No.: 3047755-18-7

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE)^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
HFL1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
L929	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
NIH3T3	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
Vero	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]

Chemical Information

CAS No. 3047755-18-7
Masse moléculaire 215.29
Formule C₁₀H₂₁N₃O₂
SMILES

CC(CCCNCCNC(/C=N/O)=O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Vishakantegowda AG, et al. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129504. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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KR-27425

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KR-27425 Related Classifications

HY-156399 Related Classifications