L-156602
L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH).
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- CAS No.: 125228-51-5
- Formule: C38H64N8O13
- Masse moléculaire:840.96
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
L-156602 (0.2-0.5 mg/kg, i.p.) suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation in PCI-induced inflammation of DBA/1 mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Dosage:0.1, 0.5 mg/kg, once daily for 3 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed the swelling completely after 4 h at 0.1 mg/kg, and the effect was still statistical after 24 h at 0.5 mg/kg.
Reduced the number of migrated leukocytes.
Suppressed the migration of neutrophils, macrophages and lymphocytes non-specifically.
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Animal Model:MDP-induced acute joint inflammation of BALB/c mice[1]
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Dosage:0.25, 0.5 mg/kg, once daily for 3 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed adjuvant arthritis although a slight reduction of body weight at the dose of 0.5 mg/kg after 24 h.
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Animal Model:0.5% PCI-induced inflammation of DBA/1 mice[2]
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Dosage:0.2, 0.5 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed ear swelling significantly and the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation.
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Animal Model:5% PCI-induced inflammation of DBA/1 mice[2]
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Dosage:0.4 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation non-specifically.
Chemical Information
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CAS No. 125228-51-5
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Masse moléculaire 840.96
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Formule C38H64N8O13
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SMILES
CC[C@@H](C[C@H]1CC[C@@]([C@@](C(N[C@H]2[C@H](C(C)C)OC([C@@H](C)N(O)C([C@H]3CCCNN3C(CNC([C@H](C)N(O)C([C@@H]4CCCNN4C2=O)=O)=O)=O)=O)=O)=O)(O)C)(O)O[C@@H]1C)C
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Synonyms
Antibiotic L 156602; PD 124966
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Tsuji RF, et al. Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation. Biosci Biotechnol Biochem. 1992 Dec;56(12):2034-6. [Content Brief]
[2]. Tsuji RF, et al. Anti-inflammatory effects and specificity of L-156,602: comparison of effects on concanavalin A and zymosan-induced footpad edema, and contact sensitivity response. Immunopharmacology. 1995 Feb;29(1):79-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-156602 Related Classifications
HY-16384 Related Classifications
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