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Cat. No.: HY-183282

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LC-U7-44

LC-U7-44 is a potent USP7 inhibitor with an IC₅₀of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₈H₃₂N₆O₃
Masse moléculaire:500.59

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LC-U7-44 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

USP7

0.96 μM (IC₅₀)

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In Vitro

LC-U7-44 (10 μM; 20-30 min) potently inhibits purified USP7 protein with an IC₅₀ of 0.96 μM in a fluorescence polarization binding assay^[1].
LC-U7-44 potently inhibits the enzymatic activity of purified USP7 protein with an IC₅₀ of 0.46 μM in a Ub-Rho assay^[1].
LC-U7-44 (0.01-100 μM; 6 days) potently inhibits the proliferation of LNCaP cells with an IC₅₀ of 1.83 μM following 6 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

lymph node carcinoma of the prostate (LNCaP) cells
Concentration:

0.01-100 μM
Incubation Time:

6 days
Result:

Suppressed LNCaP cell proliferation with an IC₅₀ of 1.83 μM.

Chemical Information

Masse moléculaire 500.59
Formule C₂₈H₃₂N₆O₃
SMILES

CN1N=C2C(N=CN(CC3(O)CCN(C(CCC4=CC=CC=C4)=O)CC3)C2=O)=C1C5=CC=C(CN)C=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chen S, et al. Development and validation of a fluorescence polarization-based assay for USP7: From probe design to inhibitor evaluation. Eur J Med Chem. 2026;312:118857. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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LC-U7-44

Voir tous les produits spécifiques à Isoform Deubiquitinase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LC-U7-44 Related Classifications

HY-183282 Related Classifications