LI-633
LI-633 is a selective and orally active GABAA receptor positive allosteric modulator (PAM) with a Ki of 21 nM. LI-633 produces robust potentiation of GABA-induced inward current, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2). LI-633 potentiates muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons with an EC50 of 70.4 nM. LI-633 can be used for the study of visceral pain.
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- CAS No.: 1849624-82-3
- Formule: C18H11ClFN3O2
- Masse moléculaire:355.75
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Chemical Information
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CAS No. 1849624-82-3
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Masse moléculaire 355.75
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Formule C18H11ClFN3O2
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SMILES
O=C(C1=CN(C2=C(C(C3=C(C=CC=C3)F)=NC4)C=C(Cl)C=C2)C4=N1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LI-633 Related Classifications
HY-185007 Related Classifications
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