MG-Lin2
MG-Lin2 is a Lin28 molecular glue degrader. It induces the formation of a ternary complex between Lin28 and the E3 ubiquitin ligase RNF126, mediates the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the abundance and function of mature let-7 miRNA. MG-Lin2 can be used in studies of ovarian cancer and choriocarcinoma.
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- Formule: C29H27F3N6O2
- Masse moléculaire:548.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
MG-Lin2 (0.1-100 μM; 24 h) showed
a proper dose-response relationship, with a significant reduction in luciferase intensity at 0.1 μM.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Masse moléculaire 548.56
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Formule C29H27F3N6O2
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SMILES
CC1=NN=C2C=CC(C3=CC=CC(N(C(C4CCN(CC4)C(/C=C/C5=CC=C(C=C5)C(F)(F)F)=O)=O)C)=C3)=NN12
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MG-Lin2 Related Classifications
HY-177732 Related Classifications
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