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Cat. No.: HY-100230

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ML-133

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

ML133 is a selective K_ir2 family channels inhibitor, with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

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CAS No.: 185669-79-8
Formule: C₁₉H₁₉NO
Masse moléculaire:277.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ML-133 Chemical Structure

CAS No.: 185669-79-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (3)
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

ML133 is a selective K_ir2 family channels inhibitor, with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5^[1].

IC₅₀ & Target

IC50: 1.8 μM (K_ir2 at pH 7.4), 290 nM (K_ir2 at pH 8.5)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.8 μM Compound: 162, ML133	Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique	[PMID: 23121096]

Chemical Information

CAS No. 185669-79-8
Masse moléculaire 277.36
Formule C₁₉H₁₉NO
SMILES

COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Cell Metab

Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. [Abstract]

2022 Nov 1;34(11):1843-1859.e11. PMID: 36103895
Pharmacol Res

Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection. [Abstract]

2022 Feb 2;177:106112. PMID: 35122955
Cell Death Dis

Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells. [Abstract]

2026 Jun 16. PMID: 42303628

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

ML-133

3 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Pureté et documentation
Références

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ML-133

Publications Citing Use of MedChemExpress (MCE) ML-133

Activité biologique

Chemical Information

Publications (3)

Pureté et documentation

Références

Calculators

Help & FAQs

ML-133 Related Classifications

HY-100230 Related Classifications