1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML133 hydrochloride

ML133 hydrochloride 

Cat. No.: HY-100230A Purity: 99.89%
Handling Instructions

ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

For research use only. We do not sell to patients.

ML133 hydrochloride Chemical Structure

ML133 hydrochloride Chemical Structure

CAS No. : 1222781-70-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 210 In-stock
Estimated Time of Arrival: December 31
100 mg USD 350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

IC50 & Target

IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].

Molecular Weight

313.82

Formula

C₁₉H₂₀ClNO

CAS No.

1222781-70-5

SMILES

COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (398.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1865 mL 15.9327 mL 31.8654 mL
5 mM 0.6373 mL 3.1865 mL 6.3731 mL
10 mM 0.3187 mL 1.5933 mL 3.1865 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ML133 hydrochloride
Cat. No.:
HY-100230A
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