MLS8969
MLS8969 is a selective human cytomegalovirus (HCMV) entry inhibitor with an EC50 of 0.12 μM (HFFs). MLS8969 reduces viral protein levels and inhibits nuclear staining of HCMV pp65. MLS8969 can be used in studies related to human cytomegalovirus infection.
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- CAS No.: 347337-33-1
- Formule: C19H15ClN2O4
- Masse moléculaire:370.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HCMV 0.12 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | CC50 |
>500 μM
Compound: MLS8969
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Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs or 10 days by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs or 10 days by MTT assay
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[PMID: 32191456] |
| HFF | CC50 |
500 μM
Compound: MLS8969
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Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs or 10 days by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs or 10 days by MTT assay
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[PMID: 32191456] |
MLS8969 potently inhibits HCMV strains in human foreskin fibroblasts (HFFs), with an EC50 of 0.12 μM[1].
MLS8969 exhibits multiplicity of infection (MOI)-dependent inhibition of pp28-luciferase reporter activity in human foreskin fibroblasts (HFFs) infected with human cytomegalovirus (HCMV), with strong inhibition at low MOI and extremely weak inhibition at an MOI of 1 PFU/cell[1].
MLS8969 reduces the protein levels of HCMV IE1/2, pp65, UL84 and UL44 in human foreskin fibroblasts (HFFs) when administered prior to infection at a multiplicity of infection (MOI) of 0.01 PFU/cell; however, it does not inhibit viral protein expression at an MOI of 1 PFU/cell[1].
MLS8969 inhibits human cytomegalovirus (HCMV) entry into human foreskin fibroblasts (HFFs)[1].
MLS8969 acts synergistically with Ganciclovir (HY-13637) and letermovir to inhibit the replication of human cytomegalovirus (HCMV) in human foreskin fibroblasts (HFFs)[1].
MLS8969 (0.16-2.5 µM; 72 h) inhibits CMV replication in human foreskin fibroblasts, with an EC50 of 0.25 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 347337-33-1
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Masse moléculaire 370.79
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Formule C19H15ClN2O4
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SMILES
O=C(NC1=CC=C(C=C1)NC(=O)C2=CC(Cl)=CC=C2OC)C=3OC=CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kapoor A, et al. Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. J Med Chem. 2020;63(8):3896-3907. [Content Brief]
[2]. Guo X, et al. The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides. Viruses. 2022;14(2):234. Published 2022 Jan 25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLS8969 Related Classifications
HY-137889 Related Classifications
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