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Cat. No.: HY-139877

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OXS007417

OXS007417 induces differentiation of acute myeloid leukemia cells (EC₅₀ = 48 nM) in vitro and shows antitumor effects in vivo.

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CAS No.: 2761147-94-6
Formule: C₂₀H₁₄F₃N₃O
Masse moléculaire:369.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

OXS007417 Chemical Structure

CAS No.: 2761147-94-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

OXS007417 induces differentiation of acute myeloid leukemia cells (EC₅₀ = 48 nM) in vitro and shows antitumor effects in vivo.

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	48 nM Compound: 28; 0X5007417	Induction of differentiation of human HL-60 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human HL-60 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]
OCI-AML-3	EC₅₀	87 nM Compound: 28; 0X5007417	Induction of differentiation of human OCI-AML-3 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human OCI-AML-3 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]
THP-1	EC₅₀	118 nM Compound: 28; 0X5007417	Induction of differentiation of human THP-1 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis Induction of differentiation of human THP-1 cells assessed as increase in CD11b positive cells after 4 days by phycoerythrin/DAPI staining-based flow cytometric analysis	[PMID: 34672555]

Chemical Information

CAS No. 2761147-94-6
Masse moléculaire 369.34
Formule C₂₀H₁₄F₃N₃O
SMILES

FC(F)OC(C=C1)=CC=C1N2C=NC3=CN=C(C4=C(C)C=C(F)C=C4)C=C32
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Josa-Culleré L, et al. A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo. J Med Chem. 2021 Nov 11;64(21):15608-15628. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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