Plaunotol
Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .
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- CAS No.: 64218-02-6
- Formule: C20H34O2
- Masse moléculaire:306.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1[2].
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1[2].
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colon cancer cell line DLD1
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Concentration:0, 10, 20, or 40 μM
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Incubation Time:24 or 48 h
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Result:Inhibited the proliferation of human colon cancer cell line DLD1 after 48 h.
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Cell Line:human colon cancer cell line DLD1
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Concentration:40 μM
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Incubation Time:24 or 48 h
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Result:Caused a significant increase in the population of Annexin V [+] apoptotic cells.
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Cell Line:human colon cancer cell line DLD1
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Concentration:40 μM
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Incubation Time:48 h
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Result:Induced PARP cleavage, and showed activation of caspase-3.
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 [3].
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3]
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Dosage:10, 25 or 50 mg/kg
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Administration:Oral administration
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Result:Plaunotol attenuated the severity of the gastric mucosal lesions.
Chemical Information
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CAS No. 64218-02-6
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Masse moléculaire 306.48
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Formule C20H34O2
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(CO)=C/CC/C(C)=C/CO
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Synonyms
CS-684
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[2]. Oshikawa N, et al. Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. J Surg Res. 2009 May 15;153(2):246-53. [Content Brief]
[3]. Ohta Y, et al. Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacology. 2005 Jul;74(4):182-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Plaunotol Related Classifications
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