(+)-PM 92131
(+)-PM 92131 is the active enantiomer of (±)-PM 92131 (HY-177437). (+)-PM 92131 is a non-nucleoside HIV-1 inhibitor. (+)-PM 92131 has an anti-HIV-1 activity with EC50s of 0.8 and 0.6 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (+)-PM 92131 can be used for HIV infections research.
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- CAS No.: 167937-11-3
- Formule: C16H20O3
- Masse moléculaire:260.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | EC50 |
0.6 μM
Compound: PM-92131(+)
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Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells
Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | EC50 |
0.8 μM
Compound: PM-92131(+)
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Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells
Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | EC50 |
1.3 μM
Compound: PM-92131(+/-)
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Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells
Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | EC50 |
1.7 μM
Compound: PM-92131(+/-)
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Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells
Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | IC50 |
134.6 μM
Compound: PM-92131(+)
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Compound was evaluated for inhibitory activity against cell growth
Compound was evaluated for inhibitory activity against cell growth
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | IC50 |
42.1 μM
Compound: PM-92131(+)
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Compound was evaluated for inhibitory activity against cell growth
Compound was evaluated for inhibitory activity against cell growth
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | IC50 |
45.7 μM
Compound: PM-92131(+/-)
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Compound was evaluated for inhibitory activity against cell growth
Compound was evaluated for inhibitory activity against cell growth
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10.1016/0960-894X(95)00260-Z |
| CEM-SS | IC50 |
53.8 μM
Compound: PM-92131(+/-)
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Compound was evaluated for inhibitory activity against cell growth
Compound was evaluated for inhibitory activity against cell growth
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10.1016/0960-894X(95)00260-Z |
Chemical Information
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CAS No. 167937-11-3
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Masse moléculaire 260.33
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Formule C16H20O3
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SMILES
C[C@@]12[C@@]3(C(C)(CCC2)C)[C@](C([C@H]1C4=COC=C4)=O)([H])O3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-PM 92131 Related Classifications
HY-177437A Related Classifications
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