CD97
CD97 (ADGRE5) is a leukocyte-enriched adhesion GPCR that undergoes GAIN-domain autoproteolysis into tethered N- and C-terminal fragments. Alternative splicing of its extracellular EGF modules generates isoforms with different ligand-binding properties; the longest isoform binds CD55 (decay-accelerating factor) on neighboring cells, while other regions engage chondroitin sulfate, linking CD97 to leukocyte migration, adhesion and activation at inflammatory sites. CD97 is expressed on granulocytes, monocytes and activated T cells, and is strongly upregulated in thyroid carcinoma, glioblastoma and other tumors, where it correlates with invasiveness. Blocking antibodies against CD97 are being explored for tumor targeting.
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CD97 Protéines Recombinantes (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
