Rolapitant-d4
Rolapitant-d4 (SCH619734-d4) is the deuterated-labeled Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.
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- Formule: C25H22D4F6N2O2
- Masse moléculaire:504.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 552292-08-7
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Masse moléculaire 504.50
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Formule C25H22D4F6N2O2
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SMILES
FC(F)(F)C1=CC(C(F)(F)F)=CC(C(C([2H])([2H])[2H])([2H])OC[C@]2(C3=CC=CC=C3)CC[C@]4(NC(CC4)=O)CN2)=C1
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Synonyms
SCH619734-d4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rolapitant-d4 Related Classifications
HY-14751S Related Classifications
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