Sarcophine
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum.
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- CAS No.: 55038-27-2
- Formule: C20H28O3
- Masse moléculaire:316.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
10.38 μg/mL
Compound: 6
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Cytotoxicity against human A549 cells after 6 days by MTT assay
Cytotoxicity against human A549 cells after 6 days by MTT assay
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10.1021/np960174n |
| A549 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
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[PMID: 21458279] |
| HCT-116 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
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[PMID: 21458279] |
| HL-60 | IC50 |
34.7 μM
Compound: 5
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Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
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[PMID: 21458279] |
| HT-29 | ED50 |
10.46 μg/mL
Compound: 6
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Cytotoxicity against human HT29 cells after 6 days by MTT assay
Cytotoxicity against human HT29 cells after 6 days by MTT assay
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10.1021/np960174n |
| KB | ED50 |
>50 μg/mL
Compound: 6
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Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
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10.1021/np960174n |
| MCF7 | IC50 |
>40 μM
Compound: 5
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Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
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[PMID: 21458279] |
| P388 | ED50 |
2.42 μg/mL
Compound: 6
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Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
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10.1021/np960174n |
In Vitro
Sarcophine ((+)-Sarcophine) is an inhibitor of recombinant glycine receptors, with a Ki value of 2.1 μM[1].
Sarcophine (1-100 mM; 24 h) has cytotoxicity against HEK293 cells with an LD50 value of 29.3 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 55038-27-2
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Masse moléculaire 316.43
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Formule C20H28O3
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SMILES
O=C1C(C)=C2[C@](O1)([H])/C=C(C)/CC[C@H]3[C@](O3)(C)CC/C=C(C)/CC2
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Synonyms
(+)-Sarcophine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarcophine Related Classifications
HY-124550 Related Classifications
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