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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
GHS-R
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "GHS-R" in MCE Product Catalog:
5
Target:
Domaines de recherche:
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.
3
3 Cited Publications
Cat. No.: HY-U00433
CAS No.: 925238-89-7
Target:
Domaines de recherche:
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
3
3 Cited Publications
Cat. No.: HY-U00433A
CAS No.: 2448414-54-6
Target:
Domaines de recherche:
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
2
Target:
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-P5645
CAS No.: 1683582-94-6
Synonyms: Human liver expressed antimicrobial peptide-2
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-P1366
CAS No.: 293735-04-3
Target:
Domaines de recherche:
1
Synonyms: EP-1572 acetate; AEZS-130 acetate
Target:
Domaines de recherche:
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) .
Synonyms: CP 424391-18
Target:
Domaines de recherche:
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
Target:
Domaines de recherche:
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively .
Cat. No.: HY-171962A
CAS No.: 2376132-24-8
Target:
Domaines de recherche:
KARI 201 hydrochloride is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 hydrochloride is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 hydrochloride competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 hydrochloride activates GHSR-1a and induces calcium influx. KARI 201 hydrochloride ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 hydrochloride can be used in Alzheimer's disease-related research .
Cat. No.: HY-P1139
CAS No.: 485803-62-1
Synonyms: PCFWKTCK
Target:
Domaines de recherche:
Cat. No.: HY-50760
CAS No.: 145455-35-2
Target:
Domaines de recherche:
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release .
Target:
Domaines de recherche:
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively .
Cat. No.: HY-N3298
CAS No.: 23971-42-8
Cat. No.: HY-171962
CAS No.: 2376132-22-6
Target:
Domaines de recherche:
KARI 201 is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 activates GHSR-1a and induces calcium influx. KARI 201 ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 can be used in Alzheimer's disease-related research .
Cat. No.: HY-P3595
CAS No.: 88384-73-0
Target:
Domaines de recherche:
Cat. No.: HY-14820
CAS No.: 381231-18-1
Synonyms: EP-1572; AEZS-130
Target:
Domaines de recherche:
Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS) .
Cat. No.: HY-19884
CAS No.: 661472-41-9
Synonyms: RM-131; BIM-28131
Target:
Domaines de recherche:
Cat. No.: HY-137061
CAS No.: 1143020-91-0
Target:
Domaines de recherche:
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
