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Cat. No.: HY-P11863

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SMIC-1014

SMIC-1014 is a cellular mesenchymal-epithelial transition factor (c-Met) ligand. SMIC-1014 binds to the c-Met ectodomain without activating c-Met phosphorylation or inducing receptor internalization. SMIC-1014, when radiolabeled as [⁶⁸Ga]Ga-SMIC-1014, acts as a positron emission tomography (PET) probe with defined pharmacokinetics, achieves specific tumor uptake in xenografts, and functions as a c-Met-targeted diagnostic probe. SMIC-1014 can be used for the research of colon cancer, hepatocellular carcinoma, prostate cancer.

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Formule: C₅₂H₈₀N₁₆O₁₆
Masse moléculaire:1185.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

SMIC-1014 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

SMIC-1014 is a cellular mesenchymal-epithelial transition factor (c-Met) ligand. ^[1] SMIC-1014 binds to the c-Met ectodomain without activating c-Met phosphorylation or inducing receptor internalization. ^[1] SMIC-1014, when radiolabeled as [⁶⁸Ga]Ga-SMIC-1014, acts as a positron emission tomography (PET) probe with defined pharmacokinetics, achieves specific tumor uptake in xenografts, and functions as a c-Met-targeted diagnostic probe. ^[2] SMIC-1014 can be used for the research of colon cancer, hepatocellular carcinoma, prostate cancer^[1].

In Vitro

SMIC-1014 (10^-3 to 10^-10 M; 60 min) competes with [⁶⁸Ga]Ga-SMIC-1014 for binding to c-Met on HCT-116 cells, with an IC₅₀ of 116.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1185.29
Formule C₅₂H₈₀N₁₆O₁₆
Sequence

{βAla}-d{Arg-Leu-Asp}-Gly-d{Pro-Glu}-Gly-d{Pro-Phe-Gln}-NH2
Sequence Shortening

{βAla}-d{RLD}-G-d{PE}-G-d{PFQ}-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Luo R, et al.. Harnessing Insights of Hepatocyte Growth Factor Kringle 3 Domain to Develop c-Met Targeted Positron Emission Tomography Probe. Journal of medicinal chemistry. 2026 Jan 08;69(1):488-500. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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