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Cat. No.: HY-139103

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Thailanstatin C

Thailanstatin C is a pre-mRNA splicing inhibitor (IC₅₀= 6.84 μM) and antiproliferative agent from Burkholderia thailandensis MSMB43.

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CAS No.: 1426953-24-3
Formule: C₃₀H₄₆ClNO₉
Masse moléculaire:600.14

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Thailanstatin C Chemical Structure

CAS No.: 1426953-24-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Thailanstatin C is a pre-mRNA splicing inhibitor (IC₅₀= 6.84 μM) and antiproliferative agent from Burkholderia thailandensis MSMB43^[1].

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	2.98 nM Compound: 3	Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
HEK293	IC₅₀	6.84 μM Compound: 3	Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay	[PMID: 23517093]
HEK-293T	IC₅₀	64.7 nM Compound: 7	Cytotoxicity against HEK293T cells assessed as inhibition in cell growth Cytotoxicity against HEK293T cells assessed as inhibition in cell growth	[PMID: 33974423]
MDA-MB-231	GI₅₀	8.82 nM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
MES-SA	IC₅₀	136.7 nM Compound: 7	Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth	[PMID: 33974423]
MES-SA/Dx5	IC₅₀	298.5 nM Compound: 7	Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth	[PMID: 33974423]
SK-OV-3	GI₅₀	5.57 nM Compound: 3	Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]

In Vitro

Thailanstatin C inhibits human cancer cell lines with IC₅₀s of 2.98-8.82 nM for DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1426953-24-3
Masse moléculaire 600.14
Formule C₃₀H₄₆ClNO₉
SMILES

C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C(C)C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2[C@H]([C@@](O)(C[C@H](O2)CC(O)=O)CCl)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Burkholderia thailandensis
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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Thailanstatin C

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Thailanstatin C Related Classifications

HY-139103 Related Classifications