TR79
TR79 is a mitochondrial ClpP protease activator with an EC50 of 414.49 nM. TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation. TR79 can be used in research on mitochondria-related diseases (such as cancer and neurodegenerative diseases) and mitochondrial metabolic abnormalities.
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- CAS No.: 2365073-59-0
- Formule: C26H26F3N5O2
- Masse moléculaire:497.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
TR79 is a potent ClpP agonist, with an EC50 of 414.49 nM in the ClpP activation assay[1].
TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation in cultured cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2365073-59-0
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Masse moléculaire 497.51
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Formule C26H26F3N5O2
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SMILES
NCCCN(C1=C(CN(CC2=CC=CC(C#N)=C2)CC1)C(N3CC4=CC=C(C(F)(F)F)C=C4)=O)C3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Chen C, et al. Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond. JACS Au. 2026 Sep 28;6(9):5439-5454. [Content Brief]
[2]. Yamada W, et al. Targeted protein degradation in the mitochondrial matrix and its application to chemical control of mitochondrial morphology. Chem Sci. 2024 Aug 28;15(36):14625-14634. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TR79 Related Classifications
HY-189815 Related Classifications
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