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Cat. No.: HY-129558

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UK-1

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UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities. UK-1 also inhibits HCV replication.

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Pureté: 95.0%
CAS No.: 151271-53-3
Formule: C₂₂H₁₄N₂O₅
Masse moléculaire:386.36

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

UK-1 Chemical Structure

CAS No.: 151271-53-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities^[1]. UK-1 also inhibits HCV replication^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs in presence of CuCl2 Cytotoxicity against human A549 cells after 72 hrs in presence of CuCl2	[PMID: 18037301]
A549	IC₅₀	1 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs Cytotoxicity against human A549 cells after 72 hrs	[PMID: 18037301]
A549	IC₅₀	17 μM Compound: UK-1	Cytotoxicity against human A549 cells after 24 hrs Cytotoxicity against human A549 cells after 24 hrs	[PMID: 18037301]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells by Alamar blue assay Cytotoxicity against human A549 cells by Alamar blue assay	[PMID: 18037301]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]
A549	IC₅₀	2 μM Compound: UK-1	Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay	[PMID: 23123017]
A549	IC₅₀	4.5 μM Compound: UK-1	Cytotoxicity against human A549 cells after 24 hrs in presence of CuCl2 Cytotoxicity against human A549 cells after 24 hrs in presence of CuCl2	[PMID: 18037301]
HL-60	IC₅₀	0.32 μM Compound: UK-1	Cytotoxicity of compound against HL60 cell line Cytotoxicity of compound against HL60 cell line	[PMID: 15149679]
Huh-7	CC₅₀	17 μM Compound: UK-1	Cytotoxicity against human Huh7ET cells by neutral red assay Cytotoxicity against human Huh7ET cells by neutral red assay	[PMID: 24360997]
Huh-7	EC₅₀	0.77 μM Compound: UK-1	Antiviral activity against HCV infected in human Huh7ET cells assessed as inhibition of viral replication by luciferase reporter gene assay/RNA blot hybridization analysis Antiviral activity against HCV infected in human Huh7ET cells assessed as inhibition of viral replication by luciferase reporter gene assay/RNA blot hybridization analysis	[PMID: 24360997]
MCF7	IC₅₀	1.2 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs in presence of CuCl2 Cytotoxicity against human MCF7 cells after 72 hrs in presence of CuCl2	[PMID: 18037301]
MCF7	IC₅₀	1.4 μM Compound: UK-1	Cytotoxicity against human MCF7 cells by Alamar blue assay Cytotoxicity against human MCF7 cells by Alamar blue assay	[PMID: 18037301]
MCF7	IC₅₀	1.4 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay	[PMID: 18752870]
MCF7	IC₅₀	1.7 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 72 hrs Cytotoxicity against human MCF7 cells after 72 hrs	[PMID: 18037301]
MCF7	IC₅₀	31 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 24 hrs Cytotoxicity against human MCF7 cells after 24 hrs	[PMID: 18037301]
MCF7	IC₅₀	4.6 μM Compound: UK-1	Cytotoxicity against human MCF7 cells after 24 hrs in presence of CuCl2 Cytotoxicity against human MCF7 cells after 24 hrs in presence of CuCl2	[PMID: 18037301]
P388	IC₅₀	0.3 μM Compound: UK-1	Inhibitory activity of compound against P388 murine cell line; range is 0.3 uM-1.6 uM Inhibitory activity of compound against P388 murine cell line; range is 0.3 uM-1.6 uM	[PMID: 15149679]
PC-3	IC₅₀	0.4 μM Compound: UK-1	Cytotoxicity of compound against PC-3 cell line Cytotoxicity of compound against PC-3 cell line	[PMID: 15149679]

Chemical Information

CAS No. 151271-53-3
Appearance Solid
Masse moléculaire 386.36
Formule C₂₂H₁₄N₂O₅
Color Yellow to orange
SMILES

O=C(C1=C2N=C(C3=C4N=C(C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1993 Jul;46(7):1089-94. [Content Brief]

[2]. Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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