URB694
URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
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- CAS No.: 904672-77-1
- Formule: C19H21NO3
- Masse moléculaire:311.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
URB694 (0.3 mg/kg; i.p.) reduces isoproterenol hydrochloride (ISOP; HY-B0468)-induced arrhythmia occurrence in HAB rats, whereas it has no significant effects in NAB and LAB rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-month-old male Wistar rats (350-450 g) selectively bred for high (HAB) and low (LAB) anxiety-related behavior in the elevated plus-maze test or non-selected rats (NAB)[1]
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Dosage:0.3 mg/kg
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Administration:Administered intraperitoneally to rats in a volume of 0.5 mL/kg
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Result:Significantly increased the time spent by HAB rats on the open arms.
Had no effects on NABs’ and LABs’ behavioral performance in the elevated plus maze test.
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Animal Model:HAB, NAB and LAB rats[1]
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Dosage:0.3 mg/kg
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Administration:Received the i.p. injection 30 min before ISOP (0.02 mg/kg)
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Result:Significantly reduced ISOP-induced arrhythmia occurrence in HAB rats compared to vehicle pretreatment condition.
Had no significant effects in NAB and LAB rats.
Chemical Information
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CAS No. 904672-77-1
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Masse moléculaire 311.37
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Formule C19H21NO3
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SMILES
O=C(OC=1C=CC(O)=C(C1)C=2C=CC=CC2)NC3CCCCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218. [Content Brief]
[2]. Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55(12):1993-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
URB694 Related Classifications
HY-W728451 Related Classifications
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