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WRW4 TFA

16 Cited Publications
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Based on 16 publication(s) in Google Scholar

WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide.

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  • Formule: C63H66F3N15O8
  • Masse moléculaire:1218.29
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • WRW4 TFA Chemical Structure
    WRW4 TFA Chemical Structure
  • Experimental Validation Results for WRW4 TFA
  • Experimental Validation Results for WRW4 TFA
  • Experimental Validation Results for WRW4 TFA
  • Experimental Validation Results for WRW4 TFA
  • Experimental Validation Results for WRW4 TFA
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Histological Imaging/StainingIFIHCELISA
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  • WRW4 TFA Chemical Structure
    WRW4 TFA Chemical Structure
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    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2023 Jan 19;28(1):4. [Abstract]

    Customer Validation
     Inhibition of elevated FPR2 is protective against kidney injury. The left renal pedicle of the rat was clamped for 45 min to induce IRI. The right kidney was removed before releasing the clamps. WRW4 (10 mg/kg; single dose) was administered intravenously 30 min before surgery. Serum or kidney tissues were collected 24 h after surgery. Kidney tissues were sectioned for histological examination and TUNEL staining. Scale bar, 100 μm. TUNEL staining results showed a decrease in the number of apoptotic renal tubular cells in the WRW4 pretreatment group compared with the surgical group.

  • 1/16

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2023 Jan 19;28(1):4. [Abstract]

    Customer Validation
     Inhibition of FPR2 reduces neutrophil infiltration in IRI kidneys. The left renal pedicle of the rat was clamped for 45 min to induce IRI. The right kidney was removed before releasing the clamps. WRW4 (10 mg/kg; single dose) was administered intravenously 30 min before surgery. Kidney tissues were collected 24 h after surgery. A Immunochemistry staining of CD68+ macrophages and MPO+ neutrophils. Scale bar, 100 μm.

  • 1/16

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cancer Res. 2022 Aug 16;82(16):2887-2903. [Abstract]

    Customer Validation
     Detection of PLD activity and PA production in the indicated cells. Cells were treated with cyclosporine H (5 μmol/L; FPR1 inhibitor) or WRW4 (10 μmol/L; FPR2 inhibitor) for 1 hour. The fold increases after D-AS2 overexpression and fold decreases after D-AS2 depletion are shown.

  • 1/16

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2022 Aug 31;70(34):10532-10542. [Abstract]

    Customer Validation
     Positive expression of p65 in liver tissue was observed by immunofluorescence staining under a laser scanning confocal microscope. The p65 cells were marked in red, and the nucleus was stained with 4′,6-diamidino-2-phenylindole (DAPI) in blue. Scale bars = 50 μm. The results showed that the expression level of p65 within the hepatocytes' nuclei was elevated in the CRS group rats; in the CRS + CGA group, the p65 expression level was reduced; furthermore, this effect of CGA was reversed by WRW4 (0.1 mg/kg; i.p.).

  • 1/16

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2022 Aug 31;70(34):10532-10542. [Abstract]

    Customer Validation
     Levels of serum RvD1 and RvD1 in liver tissue. ELISA results showed that RvD1 levels in serum and liver were significantly lower in CRS rats than in CON rats, and significantly higher in CGA-treated rats; this effect was prevented by WRW4 (0.1 mg/kg; i.p.).

  • WRW4 TFA