XR5944
Based on 1 Customer Validation
XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer.
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- Pureté: 97.39%
- CAS No.: 343247-32-5
- Formule: C34H34N8O2
- Masse moléculaire:586.69
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAKI-1 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the CAK1 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the CAK1 human cell line
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[PMID: 11311063] |
| D3F | IC50 |
4.4 nM
Compound: 8
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Concentration of the drug to reduce cell number to 50% of controls in D3F cell line
Concentration of the drug to reduce cell number to 50% of controls in D3F cell line
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[PMID: 11311063] |
| HCT-116 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HTC116 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HTC116 human cell line
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[PMID: 11311063] |
| HT-29 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HT-29 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the HT-29 human cell line
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[PMID: 11311063] |
| HT-29 | IC50 |
0.08 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in HT-29 (human colon)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in HT-29 (human colon)
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[PMID: 11311063] |
| Lewis lung carcinoma cell line | IC50 |
2.8 nM
Compound: 8
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Inhibitory concentration required to reduce cell number to 50% of control cultures in LL(Lewis lung carcinoma cell line)
Inhibitory concentration required to reduce cell number to 50% of control cultures in LL(Lewis lung carcinoma cell line)
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[PMID: 11311063] |
| MCF7 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the MCF-7 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the MCF-7 human cell line
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[PMID: 11311063] |
| MOLT-4 | IC50 |
0.0062 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in MOLT-4 (human leukemia)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in MOLT-4 (human leukemia)
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[PMID: 11311063] |
| P388 | IC50 |
21 nM
Compound: 8
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Inhibitory concentration required to reduce cell number to 50% of control cultures in P388 (murine leukemia cell line)
Inhibitory concentration required to reduce cell number to 50% of control cultures in P388 (murine leukemia cell line)
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[PMID: 11311063] |
| SK-OV-3 | GI50 |
<10 nM
Compound: 8
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Inhibitory concentration required to reduce cell growth to 50% of control cultures in the SKOV3 human cell line
Inhibitory concentration required to reduce cell growth to 50% of control cultures in the SKOV3 human cell line
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[PMID: 11311063] |
| U-937 | IC50 |
0.047 nM
Compound: 8
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in U937 (human leukemia)
Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in U937 (human leukemia)
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[PMID: 11311063] |
Chemical Information
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CAS No. 343247-32-5
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Appearance Solid
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Masse moléculaire 586.69
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Formule C34H34N8O2
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC2=NC3=CC=CC(C)=C3N=C21)NCCNCCNCCNC(C4=CC=CC5=NC6=CC=CC(C)=C6N=C54)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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