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Cat. No.: HY-129213

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CL-242817

CL-242817 is an orally available angiotensin converting enzyme (ACE) inhibitor. CL-242817 inhibits the conversion of angiotensin I to angiotensin II and has blood pressure lowering activity. CL-242817 can also improve Monocrotaline (HY-N0750) induced lung injury. CL-242817 can be used in the study of pulmonary fibrosis and hypertension-related diseases.

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CAS No.: 86709-48-0
화학식: C₁₈H₂₁NO₅S
분자량:363.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CL-242817 Chemical Structure

CAS No.: 86709-48-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

CL-242817 effectively inhibits rabbit lung ACE in vitro (IC50=54.9 nM), angiotensin I (Al) induced contraction of isolated guinea pig ileum (IC50=0.82 pM), and enhances bradykinin (BK) induced contraction of isolated guinea pig ileum (EC50=0.383 pM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CL-242817 (60 mg/kg, p.o., everyday for six weeks) causes male Wistar rats to fail to gain weight at a normal rate and significantly reduces cardiac function, significantly improves vascular occlusion and monocholinergic injury caused by Monocrotaline (HY-N0750), inhibits ACE activity and reduces hydroxyproline (HP) content in the lungs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 86709-48-0
분자량 363.43
화학식 C₁₈H₂₁NO₅S
SMILES

O=C([C@H]1N(CCC1)C([C@H]([C@@H](C(C2=CC=CC=C2)=O)SC(C)=O)C)=O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Molteni, et al. Monocrotaline-induced cardiopulmonary damage in rats: amelioration by the angiotensin-converting enzyme inhibitor CL242817. Proceedings of the Society for Experimental Biology and Medicine 182.4 (1986): 483-493. [Content Brief]

[2]. FM Lai, et al. Some in vitro and in vivo studies of a new angiotensin I‐converting enzyme inhibitor [[S‐(R*), S*]‐1‐[(3‐acetylthio)‐3‐benzoyl‐2‐methylpropionyl]‐L‐proline](CL 242,817) in comparison with captopril. Drug Development Research 3.3 (1983): 261-269.

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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