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CN128 

Cat. No.: HY-131060
Handling Instructions

CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.

For research use only. We do not sell to patients.

CN128 Chemical Structure

CN128 Chemical Structure

CAS No. : 1335282-05-7

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Based on 1 publication(s) in Google Scholar

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Description

CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].

In Vitro

CN128 possesses a high selectivity for iron(III) over others metals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].
The iron removal efficacies of CN128 displays a dose-dependent behavior[1].
CN128 lacks genetic toxicity[1].
CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].
CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (300 g)[1]
Dosage: 450 μmol/kg
Administration: Oral gavage, 1 hour after 59Fe-ferritin injection
Result: Exhibited good iron scavenging activity.
Animal Model: Sprague-Dawley rats (200~250 g)[1]
Dosage: 75 μmol/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC values= 16.38 mg/L•h, Cmax=8.671 mg/L.
Clinical Trial
Molecular Weight

295.76

Formula

C₁₅H₁₈ClNO₃

CAS No.

1335282-05-7

SMILES

CC1=C(O)C(O)=CC=[N+]1[[email protected]](CC2=CC=CC=C2)CO.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CN128CN 128CN-128Othersironchelatorexcretionfacilitatesβ-thalassemiaInhibitorinhibitorinhibit

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