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CN128 hydrochloride  (Synonyms: CN328)

Cat. No.: HY-131060 Purity: 99.01%
COA Handling Instructions

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.

For research use only. We do not sell to patients.

CN128 hydrochloride Chemical Structure

CN128 hydrochloride Chemical Structure

CAS No. : 1335282-05-7

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Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Solid
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10 mg USD 300 In-stock
50 mg USD 850 In-stock
100 mg USD 1250 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].

In Vitro

CN128 hydrochloride possesses a high selectivity for iron(III) over others metals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].
The iron removal efficacies of CN128 displays a dose-dependent behavior[1].
CN128 hydrochloride lacks genetic toxicity[1].
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (300 g)[1]
Dosage: 450 μmol/kg
Administration: Oral gavage, 1 hour after 59Fe-ferritin injection
Result: Exhibited good iron scavenging activity.
Animal Model: Sprague-Dawley rats (200~250 g)[1]
Dosage: 75 μmol/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC values= 16.38 mg/L•h, Cmax=8.671 mg/L.
Clinical Trial
Molecular Weight

295.76

Appearance

Solid

Formula

C15H18ClNO3

CAS No.
SMILES

O=C1C(O)=C(C)N([C@@H](CO)CC2=CC=CC=C2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (338.11 mM; Need ultrasonic)

DMSO : 28.57 mg/mL (96.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3811 mL 16.9056 mL 33.8112 mL
5 mM 0.6762 mL 3.3811 mL 6.7622 mL
10 mM 0.3381 mL 1.6906 mL 3.3811 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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CN128 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
CN128 hydrochloride
Cat. No.:
HY-131060
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