1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. CyPPA

CyPPA 

Cat. No.: HY-W011509
Handling Instructions

CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1].

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CyPPA Chemical Structure

CyPPA Chemical Structure

CAS No. : 73029-73-9

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Description

CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2]>.

In Vitro

CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM[1].

In Vivo

CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice[2].

Molecular Weight

285.39

Formula

C₁₆H₂₃N₅

CAS No.

73029-73-9

SMILES

CC1=CC(NC2CCCCC2)=NC(N3N=C(C)C=C3C)=N1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CyPPAPotassium ChannelKcsAInhibitorinhibitorinhibit

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