D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium
D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium (Ins(1,3,4,5,6)P5 sodium) is a small intracellular signaling molecule. D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium inhibits the PI3K/Akt signaling pathway. D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium inhibits Akt/PKB phosphorylation and kinase activity, inducing apoptosis in cancer cells. D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium inhibits the formation of tubular structures in endothelial cells in an in vitro angiogenesis mouse model. D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium can be used in research on ovarian cancer, lung cancer, breast cancer, and other cancers, as well as in cardiovascular and cerebrovascular diseases such as angiogenesis.
For research use only. We do not sell to patients.
- Formula: C6H12Na5O21P5
- Molecular Weight:689.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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Molecular Weight 689.96
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Formula C6H12Na5O21P5
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SMILES
O[C@@H]1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O
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Synonyms
Ins(1,3,4,5,6)P5 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Maffucci T, et al. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Res. 2005 Sep 15;65(18):8339-49. [Content Brief]
[2]. Piccolo E, et al. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene. 2004 Mar 4;23(9):1754-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-myo-Inositol-1,3,4,5,6-pentaphosphate sodium Related Classifications
HY-175068 Related Classifications
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