1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor
  3. DA-JC4

DA-JC4 

Cat. No.: HY-P3255
Handling Instructions

DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DA-JC4 Chemical Structure

DA-JC4 Chemical Structure

CAS No. : 2315504-40-4

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Description

DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways[1][2][3].

IC50 & Target

GLP-1/GIP[1]

In Vitro

DA-JC4 (1~100 nM; hippocampal cells) inhibits rotenone-induced hippocampal neuron death and significantly suppresses Cyt C, Bax and Caspase activation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DA-JC4 (10 nmol/kg; i.p.; once-daily for 14 days) significantly prevents spatial learning deficits in a Y- maze test and Morris water maze tests, and decreases phosphorylated tau levels in the rat cerebral cortex and hippocampus[1].
DA-JC4 (25 nmol/kg; i.p.; 6 days) shows high levels expression of tyrosine Hydroxylase in the s. nigra and increases expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF)[2].
DA-JC4 (50 nmol/kg; i.p.; once-daily for 7 days) improves Parkinson's disease symptom potentially and enhances neurotransmission[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (210–230 g)
Dosage: 10 nmol/kg
Administration: I.p.
Result: Significantly prevented spatial learning deficits in a Y- maze test and Morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus.
Animal Model: Adult male C57BL/6 mice (8 week-old)
Dosage: 25 nmol/kg/day
Administration: I.p.
Result: Showed high levels expression of tyrosine Hydroxylase in the s. nigra and increased expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).
Animal Model: Adult male Sprague-Dawley (SD) rats (230-280 g)
Dosage: 50 nmol/kg
Administration: I.p.
Result: Improved Parkinson's disease symptom potentially and enhanced neurotransmission.
Molecular Weight

4875.49

Formula

C₂₂₅H₃₄₆N₅₆O₆₅

CAS No.
Sequence Shortening

Y-{aminoisobutyric acid}-EGTFTSDYSIYLDKQAA-{aminoisobutyric acid}-EFVNWLLAGGPSSGAPPPSKKKKKK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DA-JC4Insulin ReceptorNeurologicalInsulinParkinsonAlzheimerInflammationInhibitorinhibitorinhibit

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