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Art. -Nr.: HY-W039750

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DAAO-IN-2

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DAAO-IN-2 is a D-amino acid oxidase (DAAO) inhibitor, with an IC₅₀ of 0.123 μM against human DAAO and a K_d value of 1 μM against porcine DAAO. DAAO-IN-2 can be used for the research of schizophrenia.

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CAS. Nr.: 862274-39-3
Formel: C₇H₅FN₂O
Molecular Weight:152.13

Speicherung:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

DAAO-IN-2 Chemical Structure

CAS. Nr.: 862274-39-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Amino Acid Oxidase Isoform-spezifische Produkte anzeigen :

D-Amino acid oxidase

In Vitro

DAAO-IN-2 has a pK_a of 7.84, with partial deprotonation at physiological and DAAO-optimal pH levels^[1].
DAAO-IN-2 (4 h) exhibits medium intestinal permeability in PAMPA testing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DAAO-IN-2 (30 mg/kg; i.p.; co-administered with 30 mg/kg D-Serine (HY-100808)) significantly increases plasma D-Serine levels in mice by 33% at 10 min and by 27% at 60 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI mice (male, 25-30 g)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; single co-administration with 30 mg/kg D-serine
Result:

Increased plasma D-serine levels by 33% at 10 minutes, with a corresponding plasma level of 13.1 μM for DAAO-IN-2.
Increased plasma D-serine levels by 27% at 60 minutes, with a corresponding plasma level of 0.77 μM for DAAO-IN-2.

Chemical Information

CAS. Nr. 862274-39-3
Appearance Solid
Molecular Weight 152.13
Formel C₇H₅FN₂O
SMILES

O=C1NNC2=CC(F)=CC=C12
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Szilágyi B, et al. Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1579-1587. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- In Vivo
Chemical Information
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DAAO-IN-2

Amine Fragment Library

Alle Amino Acid Oxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DAAO-IN-2 Related Classifications

HY-W039750 Related Classifications