DBCO-PEG4-PFP ester
Based on 1 Customer Validation
DBCO-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- Formula: C36H35F5N2O8
- Molecular Weight:718.66
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Oil
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Molecular Weight 718.66
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Formula C36H35F5N2O8
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Color Colorless to light yellow
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SMILES
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCC(OC4=C(C(F)=C(C(F)=C4F)F)F)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (139.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3915 mL | 6.9574 mL | 13.9148 mL | 34.7870 mL |
| 5 mM | 0.2783 mL | 1.3915 mL | 2.7830 mL | 6.9574 mL | |
| 10 mM | 0.1391 mL | 0.6957 mL | 1.3915 mL | 3.4787 mL | |
| 15 mM | 0.0928 mL | 0.4638 mL | 0.9277 mL | 2.3191 mL | |
| 20 mM | 0.0696 mL | 0.3479 mL | 0.6957 mL | 1.7393 mL | |
| 25 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3915 mL | |
| 30 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1596 mL | |
| 40 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8697 mL | |
| 50 mM | 0.0278 mL | 0.1391 mL | 0.2783 mL | 0.6957 mL | |
| 60 mM | 0.0232 mL | 0.1160 mL | 0.2319 mL | 0.5798 mL | |
| 80 mM | 0.0174 mL | 0.0870 mL | 0.1739 mL | 0.4348 mL | |
| 100 mM | 0.0139 mL | 0.0696 mL | 0.1391 mL | 0.3479 mL |
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