2. PROTAC
  3. PROTAC Linkers
  4. DBCO-PEG6-amine TFA

DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-PEG6-amine TFA

DBCO-PEG6-amine TFA Chemical Structure

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Other Forms of DBCO-PEG6-amine TFA:

DBCO-PEG6-amine TFA Related Antibodies

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Description

DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Molecular Weight

725.75

Formula

C35H46F3N3O10
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3779 mL 6.8894 mL 13.7788 mL
5 mM 0.2756 mL 1.3779 mL 2.7558 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3779 mL 6.8894 mL 13.7788 mL 34.4471 mL
5 mM 0.2756 mL 1.3779 mL 2.7558 mL 6.8894 mL
10 mM 0.1378 mL 0.6889 mL 1.3779 mL 3.4447 mL
15 mM 0.0919 mL 0.4593 mL 0.9186 mL 2.2965 mL
20 mM 0.0689 mL 0.3445 mL 0.6889 mL 1.7224 mL
25 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3779 mL
30 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1482 mL
40 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8612 mL
50 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6889 mL
60 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5741 mL
80 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.4306 mL
100 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3445 mL
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DBCO-PEG6-amine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG6-aminePROTAC LinkersPEG-basedPROTAC linkerInhibitorinhibitorinhibit

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