1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. DC4SMe

DC4SMe 

Cat. No.: HY-135123
Handling Instructions

DC4SMe, a phosphate prodrug of cytotoxic DNA alkylator DC4, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer.

For research use only. We do not sell to patients.

DC4SMe Chemical Structure

DC4SMe Chemical Structure

CAS No. : 615538-47-1

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Description

DC4SMe, a phosphate prodrug of cytotoxic DNA alkylator DC4, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer[1].

IC50 & Target[1]

Duocarmycins

 

In Vitro

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability[1].

Molecular Weight

764.21

Formula

C₃₅H₃₁ClN₅O₇PS₂

CAS No.

615538-47-1

SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[[email protected]@H](CCl)C6=C5C=C(OP(O)(O)=O)C7=CC=CC=C67)=O)=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DC4SMeADC CytotoxinPhosphateprodrugcytotoxicDNAalkylatorRamosNamalwaHL60/scancercell targetedtreatmentInhibitorinhibitorinhibit

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