MMAD
Based on 1 Customer Validation
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.94%
- CAS. Nr.: 203849-91-6
- Formel: C41H66N6O6S
- Molecular Weight:771.06
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Speicherung:
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Monomethyl auristatin E (GMP)
Alle ADC Payloads Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
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Auristatin |
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Cell Line
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Type | Value | Description | References |
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| BT-474 | GI50 |
0.12 nM
Compound: 2, MMAD
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Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
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[PMID: 25431858] |
| MDA-MB-361 | GI50 |
0.09 nM
Compound: 2, MMAD
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Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
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[PMID: 25431858] |
| NCI-N87 | GI50 |
0.3 nM
Compound: 2, MMAD
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Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
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[PMID: 25431858] |
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 203849-91-6
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Appearance Solid
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Molecular Weight 771.06
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Formel C41H66N6O6S
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Color White to off-white
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SMILES
O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3
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Synonyms
Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (129.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2969 mL | 6.4846 mL | 12.9692 mL | 32.4229 mL |
| 5 mM | 0.2594 mL | 1.2969 mL | 2.5938 mL | 6.4846 mL | |
| 10 mM | 0.1297 mL | 0.6485 mL | 1.2969 mL | 3.2423 mL | |
| 15 mM | 0.0865 mL | 0.4323 mL | 0.8646 mL | 2.1615 mL | |
| 20 mM | 0.0648 mL | 0.3242 mL | 0.6485 mL | 1.6211 mL | |
| 25 mM | 0.0519 mL | 0.2594 mL | 0.5188 mL | 1.2969 mL | |
| 30 mM | 0.0432 mL | 0.2162 mL | 0.4323 mL | 1.0808 mL | |
| 40 mM | 0.0324 mL | 0.1621 mL | 0.3242 mL | 0.8106 mL | |
| 50 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.6485 mL | |
| 60 mM | 0.0216 mL | 0.1081 mL | 0.2162 mL | 0.5404 mL | |
| 80 mM | 0.0162 mL | 0.0811 mL | 0.1621 mL | 0.4053 mL | |
| 100 mM | 0.0130 mL | 0.0648 mL | 0.1297 mL | 0.3242 mL |
MMAD Related Classifications
HY-15581 Related Classifications
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