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Art. -Nr.: HY-129407A

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AAF-CMK

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 102129-66-8
Formel: C₁₆H₂₂ClN₃O₃
Molecular Weight:339.82

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AAF-CMK Chemical Structure

CAS. Nr.: 102129-66-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research^[1].

In Vitro

AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF^[1].
AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U937 human promonocytic leukemia cells
Concentration:

0-20 μM
Incubation Time:

24 h
Result:

Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF.

Apoptosis Analysis^[1]

Cell Line:

U937 human promonocytic leukemia cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Increased the percentage of apoptotic cells to 55.8% in combination with TRAIL.
Increased number of cells with characteristic apoptotic morphology in groups treated with AAF-CMK and both TRAIL or TNF compared to each group treated alone.

Chemical Information

CAS. Nr. 102129-66-8
Molecular Weight 339.82
Formel C₁₆H₂₂ClN₃O₃
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Młnarczuk I, et al. AAF-cmk sensitizes tumor cells to trail-mediated apoptosis. Leuk Res. 2004 Jan;28(1):53-61. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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