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Art. -Nr.: HY-146403

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Antibacterial agent 98

Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus).

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CAS. Nr.: 2408695-41-8
Formel: C₁₇H₁₃N₅O₃S₂
Molecular Weight:399.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antibacterial agent 98 Chemical Structure

CAS. Nr.: 2408695-41-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	55.3 μM Compound: g37	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay	[PMID: 31901744]
HUVEC	IC₅₀	38.8 μM Compound: g37	Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay	[PMID: 31901744]

In Vitro

Antibacterial agent 98 (compound g37) shows antibacterial activity with an NICs of 0.1 μg/mL for S. aureus ATCC29213 and an IC₅₀ of 0.15 µM for GyrB^[1].
Antibacterial agent 98 shows cytotoxicity with IC₅₀s of 55.3, 38.8 µM for HepG2, HUVEC cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2408695-41-8
Molecular Weight 399.45
Formel C₁₇H₁₃N₅O₃S₂
SMILES

CCN1C(C(C(NC2=NN=C(S2)C3=NC=CS3)=O)=C(C4=C1C=CC=C4)O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xue W, et al. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. Eur J Med Chem. 2020 Feb 15;188:112022. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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