DMG-PEG2000-SP94

DMG-PEG2000-SP94 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. SP94 peptide: Targeting/functional ligand-the SP94 peptide (sequence SFSIIHTPILPL) specifically binds to glucose-regulated protein 78 (Grp78), which is highly expressed on the surface of hepatocellular carcinoma, achieving precise targeting of hepatocellular carcinoma.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.