DOPE-PEG2000-ANG

DOPE-PEG2000-ANG: surface decoration of liposomes and nanoparticles for blood-brain barrier (BBB) -penetrating drug delivery to the central nervous system, applicable in brain tumor therapy, neurodegenerative disease treatment, and brain imaging.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular cargo release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) ANG (Angiopep-2) peptide; a 19-amino-acid peptide derived from the Kunitz domain of aprotinin that specifically binds to low-density lipoprotein receptor-related protein-1 (LRP1), which is highly expressed on brain capillary endothelial cells forming the BBB, triggering receptor-mediated transcytosis to transport nanocarriers across the BBB into brain parenchyma for targeted delivery to brain tissues and brain tumors.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.