TICAM1 - TIR domain containing adaptor molecule 1 Gene

Also Known as TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148022

About TICAM1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,815,932-4,831,712 (from NCBI)

This gene has 1 transcript (splice variant), 103 orthologues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 10.4), duodenum (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with Toll-like Receptor 3, but not with Other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an Antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

TICAM1 Products (4)

mRNA Protein Name
NM_001385678.1 NP_001372607.1 TIR domain-containing adapter molecule 1 isoform 2
NM_001385679.1 NP_001372608.1 TIR domain-containing adapter molecule 1 isoform 3
NM_001385680.1 NP_001372609.1 TIR domain-containing adapter molecule 1 isoform 4
NM_182919.4 NP_891549.1 TIR domain-containing adapter molecule 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
12471095 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14982987 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
14530355 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in TRIF-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25636800 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
14982987 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
28049150 GOA
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21266579 GOA
involved in toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
Cellular Component GO Annotation Evidence Verweise Source
is active in early endosome IDA
IDA: Inferred from direct assay
17982077 GOA
is active in endosome IDA
IDA: Inferred from direct assay
18222170 GOA
is active in endosome membrane IDA
IDA: Inferred from direct assay
18222170 GOA
part of ripoptosome IDA
IDA: Inferred from direct assay
21737330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TICAM1 Protein Structure

RHIM

RHIM: RIP homotypic interaction motif (646 - 698)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

TIR domain-containing adapter molecule 1

  • TIR domain containing adaptor inducing interferon-beta

TICAM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TICAM1 Q8IUC6 TRIM56 Homo sapiens Q9BRZ2
Anti Tag CoIP
22948160
Intra
TICAM1 Q8IUC6 CARM1 Homo sapiens Q86X55
Anti Tag CoIP
33961781
Intra
TICAM1 Q8IUC6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
Intra
TICAM1 Q8IUC6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
19416887
Cross: Cross-species interaction Intra: Intraspecies interaction

TICAM1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82518 TRIF Antibody (YA2263) WB, IP Human, Mouse, Rat
HY-P82518A TRIF Antibody (YA2263)(PBS only) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Encephalopathy, Acute, Infection-Induced 6

  • Herpes Simplex Encephalitis, Susceptibility To, 4

  • IIAE6

  • Herpes Simplex Encephalitis 4

  • Encephalopathy, Acute, Infection-Induced , Susceptibility To, 6

  • Encephalopathy, Acute, Infection-Induced, 6, Herpes-Specific

  • Encephalopathy, Acute, Infection-Induced, 6

  • Hse4
Herpes Simplex Encephalitis

  • Hse

  • Hsv Encephalitis

  • Hsve

  • Herpes Simplex Meningo-Encephalitis

  • Herpes Simplex Neuroinvasion

  • Herpes Simplex Virus Encephalitis

  • Herpetic Encephalitis

  • Herpes Encephalitis

  • Herpes Simplex Virus 1 Encephalitis
Hepatitis A

  • Viral Hepatitis A

  • Viral Hepatitis, Type A
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Ross River Fever

  • Ross River Virus Disease

  • Ross River Virus Infection
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14517 TICAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TICAM1 VGNC VGNC:55000
Mus musculus TICAM1 MGD MGI:2147032
Macaca mulatta TICAM1 VGNC VGNC:79134
Rattus norvegicus TICAM1 RGD RGD:1590868
Felis catus TICAM1 VGNC VGNC:102714
Bos taurus TICAM1 VGNC VGNC:52887
Others TICAM1 NCBI