PHLPP1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

Also Known as SCOP; PHLPP; PPM3A; PLEKHE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23239

About PHLPP1

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:62,715,541-62,980,433 (from NCBI)

This gene has 7 transcripts (splice variants), 246 orthologues and 31 paralogues. Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine Phosphatase family. The encoded protein promotes Apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of Cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated Insulin signaling. [provided by RefSeq, Dec 2011]

PHLPP1 Products (1)

mRNA Protein Name
NM_194449.4 NP_919431.2 PH domain leucine-rich repeat-containing protein phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
18162466 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
28147277 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17386267 GOA
involved in regulation of JNK cascade IDA
IDA: Inferred from direct assay
17386267 GOA
involved in regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
24530606 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
20513427 GOA
involved in regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
17386267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHLPP1 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (692 - 709)

LRR_8

LRR_8: Leucine rich repeat (714 - 771)

LRR_1

LRR_1: Leucine Rich Repeat (918 - 939)

LRR_8

LRR_8: Leucine rich repeat (1014 - 1072)

PP2C

PP2C: Protein phosphatase 2C (1177 - 1415)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1717 a.a.
Protein Preferred Names Protein Names

PH domain leucine-rich repeat-containing protein phosphatase 1

  • PH domain-containing family E member 1

PHLPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PHLPP1 O60346 SCRIB Homo sapiens Q14160
Anti Tag CoIP
19615732
Intra
PHLPP1 O60346 SCRIB Homo sapiens Q14160
Anti Bait CoIP
21701506
Intra
PHLPP1 O60346 PRKCB Homo sapiens P05771-2
Cosedimentation
18162466
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Uterine Corpus Endometrial Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-19820 NSC45586 / Unkown
HY-RS10447 PHLPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18428 Phlpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24909 Phlpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PHLPP1 VGNC VGNC:44504
Bos taurus PHLPP1 VGNC VGNC:32840
Macaca mulatta PHLPP1 VGNC VGNC:81493
Rattus norvegicus PHLPP1 RGD RGD:621308
Felis catus PHLPP1 VGNC VGNC:107716
Mus musculus PHLPP1 MGD MGI:2138327
Others PHLPP1 NCBI