PF-06442609
PF-06442609 is an orally active γ secretase modulator, with an IC50 of 6 nM for Aβ42. PF-06442609 possesses brain good penetration.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1402002-76-9
- Formel: C24H24F4N4O3
- Molecular Weight:492.47
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
6 nM
Compound: 21, PF-06442609
|
Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production after 24 hrs by ELISA
Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production after 24 hrs by ELISA
|
[PMID: 26005540] |
| CHO-K1 | IC50 |
9.2 μM
Compound: 21, PF-06442609
|
Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay
Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay
|
[PMID: 26005540] |
Chemical Information
-
CAS. Nr. 1402002-76-9
-
Molecular Weight 492.47
-
Formel C24H24F4N4O3
-
SMILES
O=C1C(N2CCN1[C@@H](C)COC3=CC=C(F)C=C3[C@@H](C)C(F)(F)F)=CC=C(N4C=C(C)N=C4)C2=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PF-06442609 Related Classifications
HY-19550 Related Classifications
Powered by Bioz