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Art. -Nr.: HY-152512

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RLA-4842

RLA-4842 is an iron activator containing anti-androgen. RLA-4842 has anti-proliferative activity on metastatic castration-resistant prostate cancer (mCRPC) cell line.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₂H₄₆F₃N₅O₈S
Molecular Weight:837.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

RLA-4842 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

RLA-4842 is an iron activator containing anti-androgen. RLA-4842 has anti-proliferative activity on metastatic castration-resistant prostate cancer (mCRPC) cell line^[1].

In Vitro

RLA-4842 (compound 9) (0-25 µM; 10 min) inhibits LNCaP-AR cells proliferation with concentration-dependent manner^[1].
RLA-4842 (5 µM; 0-6 d) shows inhibitory for VCaP, PC3, LNCaP and C4-2B cells proliferation^[1].
RLA-4842 (5 µM; 24 h) down-regulates the expression level of KLK-2 and KLK-3 in LNCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

VCaP, PC3, LNCaP and C4-2B cells.
Concentration:

0, 0.1, 0.5, 1, 5, 10, 20 or 25 µM.
Incubation Time:

0-6 d.
Result:

Showed antiproliferative effect.

Chemical Information

Molecular Weight 837.90
Formel C₄₂H₄₆F₃N₅O₈S
SMILES

CN(C(OC1=CC=C(C=C1)N2C(N(C(C23CCC3)=O)C4=CC(C(F)(F)F)=C(C=C4)C#N)=S)=O)CCN(C(O[C@@H]5CCC[C@@]6(OOC7(C8CC9CC(CC7C9)C8)O6)C5)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gonciarz RL, et al. Elevated labile iron in castration-resistant prostate cancer is targetable with ferrous iron-activatable antiandrogen therapy. Eur J Med Chem. 2023 Jan 14;249:115110. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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