6-Formylpterin
Based on 1 Customer Validation
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 712-30-1
- Formula: C7H5N5O2
- Molecular Weight:191.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.63 μM
Compound: 6-FP
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Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
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[PMID: 37638616] |
In Vitro
6-Formylpterin (2 mM) generats intracellular ROS in HL-60 cells[1].
6-Formylpterin (0.5, 1, and 2 mM, 3 h) increases intracellular H2O2, which induces apoptosis in HL-60 cells and Jurkat cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells, Jurkat cells
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Concentration:0.5, 1, and 2 mM
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Incubation Time:3 h
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Result:Induced apoptosis in HL-60 cells[1].
Inhibited Fas-mediated apoptosis in Jurkat cells in 0.5 mM[1].
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Apoptosis Solutions
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 712-30-1
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Appearance Solid
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Molecular Weight 191.15
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Formula C7H5N5O2
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Color Yellow to brown
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SMILES
O=CC1=CN=C2N=C(N)NC(C2=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O : 33.33 mg/mL (174.37 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
1 M NaOH : 5 mg/mL (26.16 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| 1 M NaOH / H2O | 1 mM | 5.2315 mL | 26.1575 mL | 52.3149 mL | 130.7873 mL |
| 5 mM | 1.0463 mL | 5.2315 mL | 10.4630 mL | 26.1575 mL | |
| 10 mM | 0.5231 mL | 2.6157 mL | 5.2315 mL | 13.0787 mL | |
| 15 mM | 0.3488 mL | 1.7438 mL | 3.4877 mL | 8.7192 mL | |
| 20 mM | 0.2616 mL | 1.3079 mL | 2.6157 mL | 6.5394 mL | |
| 25 mM | 0.2093 mL | 1.0463 mL | 2.0926 mL | 5.2315 mL | |
| H2O | 30 mM | 0.1744 mL | 0.8719 mL | 1.7438 mL | 4.3596 mL |
| 40 mM | 0.1308 mL | 0.6539 mL | 1.3079 mL | 3.2697 mL | |
| 50 mM | 0.1046 mL | 0.5231 mL | 1.0463 mL | 2.6157 mL | |
| 60 mM | 0.0872 mL | 0.4360 mL | 0.8719 mL | 2.1798 mL | |
| 80 mM | 0.0654 mL | 0.3270 mL | 0.6539 mL | 1.6348 mL | |
| 100 mM | 0.0523 mL | 0.2616 mL | 0.5231 mL | 1.3079 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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